改良土豆展現食用疫苗的希望

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如果新的研究具有任何指示意義,那麼只需一份轉基因土豆就可能有一天能夠預防兩種致命的胃病。根據《自然-生物技術》六月號上發表的一份報告,科學家們開發出了攜帶疫苗的土豆,當餵食給小鼠時,可以使它們免受輪狀病毒和腸道致病性大腸桿菌的侵害。

研究人員一直在研究食用疫苗,但這些產品已被證明僅取得適度的成功。一個問題是腸道組織會在疫苗成分到達免疫系統之前將其降解。為了繞過這個障礙,洛馬琳達大學的威廉·朗格里奇和傑·於求助於致命的霍亂毒素(CT),這種毒素不會屈服於腸道的消化液。透過將 CT 片段與輪狀病毒和大腸桿菌的片段融合,研究人員創造了一種具有彈性的組合疫苗,然後將其摻入土豆中。

該團隊報告說,食用了這些土豆的雌性小鼠,即使在接種疫苗兩個月後,也表現出強烈的免疫反應。此外,免疫小鼠的幼崽也顯示出一定的免疫力。朗格里奇和於總結說,這項研究的結果“表明食用植物可以作為疫苗,同時預防傳染性[病毒]和細菌性疾病。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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