科學家在微小病毒中發現大腸桿菌清除劑

加入我們的科學愛好者社群!


關於支援科學新聞業

如果您喜歡這篇文章,請考慮透過以下方式支援我們屢獲殊榮的新聞業 訂閱。透過購買訂閱,您正在幫助確保未來能夠繼續產出關於塑造我們當今世界的發現和想法的具有影響力的報道。


研究人員發現了一種病毒蛋白,可以作為抗生素對抗大腸桿菌。這項新發現於今日在《科學》雜誌上宣佈,為設計藥物以對抗其他細菌(如引起肺炎、耳部感染、霍亂和萊姆病的細菌)開闢了一種新方法。

德克薩斯州農工大學的托馬斯·G·伯恩哈特和他的同事在一個名為 Q Beta 的微小病毒或噬菌體中發現了這種蛋白質。長期以來,科學家們一直想知道 Q Beta 和其他小型噬菌體是如何消除細菌的。新的研究表明,Q Beta 的殺手以與抗生素非常相似的方式完成了這一壯舉,即透過阻止細菌細胞製造其外細胞壁。因此,細胞沒有分裂和繁殖,而是走向了自我毀滅。

團隊成員道格拉斯·K·斯特拉克指出,從理論上講,製藥公司可以模仿蛋白質抗生素,例如 Q Beta 中包含的抗生素。基於這些蛋白質的藥物可以被製造成靶向多種細菌或單一病原體。“作為細菌的天然敵人,它們作為殺死細菌的方法的潛力應該早就被徹底探索,但直到現在,隨著全球抗生素耐藥性危機的出現,噬菌體才終於真正受到關注,”該報告的另一位合著者王英楠評論道。“看起來小型噬菌體是蛋白質抗生素的金礦。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

More by Kate Wong
© .