新的艾滋病疫苗保護猴子免受病毒侵害

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研究人員開發出一種新的、易於管理的疫苗,可以保護猴子免受艾滋病病毒侵害,使科學家們離研製出有效的人類疫苗更近一步。這項發現發表在9月7日出版的《細胞》雜誌上。

這種新型疫苗由耶魯大學的約翰·K·羅斯和他的同事設計,使用一種常見的牲畜病毒——水皰性口炎病毒的弱化形式,將艾滋病病毒蛋白輸送到體內。這些蛋白質刺激了七隻接受疫苗的猴子的強烈免疫反應:在研究人員用艾滋病病毒感染它們14個月後,接種疫苗的猴子仍然沒有感染艾滋病。相比之下,八隻未接種疫苗的猴子中有七隻在感染後約五個月患上了這種疾病。

基於VSV的疫苗比最近描述的DNA疫苗方法具有優勢,因為它不需要多次注射。羅斯報告說,它可以作為滴鼻劑給藥。“在發展中國家和受艾滋病毒和艾滋病嚴重影響的地區,為數百萬人注射DNA疫苗是不切實際且非常昂貴的,”他指出。“基於VSV的疫苗將是其他正在測試的疫苗的一種經濟高效且同樣成功的替代方案。我們對此感到非常興奮。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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