生長替代血管

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在組織培養中生長的血管可能有一天會幫助治癒破碎的心臟。 根據昨天在俄亥俄州舉行的 2000 年生物微機電系統和生物醫學奈米技術世界大會上公佈的初步結果,研究人員已朝著在實驗室中培育替代血管邁出了第一步,以便移植到心臟病發作患者的體內。

俄亥俄州立大學研究員尼卡諾·摩爾多萬及其同事設想的宏偉計劃包括將從血管內膜或內皮層採集的細胞播種在形狀像毛細血管的矽模具中。 然後,由此產生的培養物將透過稱為“血管晶片”的微型機器輸送到心臟。 一旦進入內部,它們就可以開始修復心臟病發作造成的損害。 摩爾多萬推測說:“我們可能無法使組織恢復到原來的形態,但我們可以嘗試使其血管再生,使心臟再次跳動,或者至少透過創造新的毛細血管來防止心臟組織死亡,這些毛細血管將盡快提供血液和氧氣。”

到目前為止,研究人員已經克服了第一個障礙:證明種子細胞可以在雕刻在柔軟、透明凝膠中的凹槽中二維生長。 儘管該計劃極其複雜,但摩爾多萬仍然抱有希望。 他評論說:“我們不得不處理大量的推測或假設,但我們的方法似乎非常有希望。 “一旦我們證明我們可以在矽上或矽內部以特定的三維形狀生長細胞,那麼我們希望回到組織。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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