馬科動物克隆障礙清除,複製騾子的誕生預示著

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根據今天發表在《科學》雜誌上的一份報告,一匹名叫愛達荷寶石的騾子是加入克隆動物行列的第一匹馬科動物。這匹出生於5月4日的小馬駒也是第一個被克隆的無生育能力的動物。

從多莉羊開始,科學家們已經成功地複製了豬、牛、貓、兔子和齧齒動物。然而,儘管進行了多次嘗試,馬和其他馬科動物的克隆仍然讓他們望而卻步。在這項新工作中,莫斯科愛達荷大學的戈登·伍茲和他的同事將騾子胎兒細胞的DNA與去核的馬卵細胞融合,並透過提高培養物中的鈣含量來誘導受操縱的卵細胞成熟。(先前的研究暗示細胞環境中低鈣濃度阻礙了發育。)然後,研究小組將305個這樣的卵母細胞植入代孕母馬體內。在愛達荷寶石出生時,還有兩匹母馬仍然懷著克隆的騾子胎兒。

伍茲和他的合作者報告說,到目前為止,愛達荷寶石——一匹名為塔茲的冠軍賽騾的兄弟姐妹——似乎發育正常。與此同時,克隆馬可能也不遠了。一個義大利團隊和一個美國團隊的母馬預計將在未來幾個月內分娩。

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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