清除阿爾茨海默氏症斑塊

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研究人員用培育出的患有阿爾茨海默氏症相關斑塊的小鼠進行實驗,成功清除了這些動物大腦中的斑塊。 之前的研究表明,疫苗可以預防斑塊的形成,但這項發表在三月份《自然醫學》雜誌上的新研究,首次證明了現有斑塊的清除。 馬薩諸塞州總醫院的布萊恩·巴克斯凱及其同事發現,透過手術將抗斑塊抗體直接應用於動物大腦,僅在幾天內就清除了 70% 的斑塊。 同樣值得注意的是,該團隊首次使用一種名為多光子顯微鏡的新裝置,在活體動物身上觀察到斑塊。

清除的斑塊附近的神經元究竟會受到怎樣的影響尚不清楚,但進一步的研究可能會闡明這個問題。 團隊成員布拉德利·海曼評論說:“一旦我們能看到斑塊在哪裡,我們也可以詢問它們區域內的神經元是否健康。” “真正的關鍵是瞭解如何改善大腦功能。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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