血液標誌物可能預示自閉症和精神發育遲滯

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科學家們已經確定了可能與兒童後期自閉症和精神發育遲滯發展相關的血液標誌物。 這項新的研究將發表在五月份的神經病學年鑑上,可能有助於更早、更準確地診斷和改進這些疾病的療法。

國家神經疾病與卒中研究所的卡琳·B·尼爾森 (Karin B. Nelson) 和她的同事研究了來自正常發育兒童以及後來發展為自閉症、精神發育遲滯或腦癱兒童的檔案新生兒血液樣本。 該團隊發現,與另外兩組兒童的血液相比,後來發展為自閉症或精神發育遲滯的兒童血液中神經生長因子的水平顯著升高。

神經生長因子在胚胎髮育過程中中樞神經系統的形成中起著關鍵作用,包括產生和組織腦細胞等。 研究人員提出,這些蛋白質的過量可能因此擾亂細胞在早期神經系統發育過程中經歷的正常週期。 然而,自閉症等疾病發展的許多生物學和遺傳機制仍然未知。 因此,尼爾森和她的同事計劃在未來繼續進行類似的研究。

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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