男性不育症新檢測方法

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無法懷孕的夫婦可能很快就能更好地查明問題的原因。根據《人類生殖》雜誌上的一份報告,一組美國和日本科學家開發出一種男性不育症檢測方法,該方法優於傳統的精液分析。

這種名為精子泛素標籤免疫分析法 (SUTI) 的新方法,旨在搜尋精子細胞中一種名為泛素的小蛋白質,泛素是損傷或缺陷的指標。研究人員使用泛素抗體篩選了來自 17 名不育患者和 2 名可育捐贈者的精子,在某些情況下證實了之前的診斷,並在另一些情況下揭示了之前無法解釋的不育原因。“泛素似乎是精液異常的通用標誌物,可以識別各種精子缺陷以及精液中的汙染物,”俄勒岡健康與科學大學的團隊成員 Peter Sutovsky 說。“在大約五分之一的夫婦中,目前的方法無法確定病因,”他補充道。“SUTI 將能夠在至少一部分病例中提供答案。”

更重要的是,團隊成員 Gerald Schatten 指出,SUTI 甚至可能在治療中發揮積極作用。“既然我們現在知道一種與缺陷精子相關的特定蛋白質,並且我們擁有針對它的抗體,那麼我們就有可能開發出一種技術,從精液樣本中去除大部分真正有缺陷的精子,用於[體外受精]或卵胞漿內單精子注射 (ICSI)——即透過注射單個精子使卵子受精的過程。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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