新型化合物控制體重增加

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我們都聽過衣著暴露的代言人在深夜電視上對快速減肥補品做出虛假宣傳。但在今天早些時候線上出版的《美國國家科學院院刊》上,研究人員描述了一種聽起來像是真材實料的東西——至少對於小鼠而言是這樣。懷特海生物醫學研究所的哈維·洛迪什及其同事發現了一種新型化合物,這種化合物可以導致餵食不限量高脂肪和高糖飲食的小鼠體重顯著減輕。這種化合物名為gAcrp30,是Acrp30蛋白的一個片段。大多數減肥藥物的作用原理是透過吸收腸道中的脂肪酸,或者透過抑制脂肪酸的分解,使其排出體外而不是儲存起來。相比之下,gAcrp30實際上可以促使肌肉更快地燃燒脂肪酸。

用該化合物治療的小鼠顯示,遊離脂肪酸水平顯著降低,葡萄糖和甘油三酯水平也降低。此外,每日低劑量的gAcrp30使小鼠能夠保持體重不增加,儘管它們吃的是自助餐式飲食。雖然結果很有希望,但現在還不要熬夜尋找電話號碼來撥打。“還需要進行更多的研究,以確定這種物質是否可以用於人類,作為減肥的輔助手段,”洛迪什評論道。“成千上萬患有糖尿病等多種相關健康問題的肥胖患者迫切需要這種療法。”

Kate Wong is an award-winning science writer and senior editor at 大眾科學 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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